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A PhD position is available at the Institute of Animal Pathology, University of Bern to join our molecular parasitology group.

PhD Position - Molecular Parasitology

Our lab works on the host pathogen interaction of intracellular parasites (www.itpa.vetsuisse.unibe.ch/research/host_pathogen_interactions/group_olias/index_eng.html)
We study the mechanisms of host cell transformation by apicomplexan parasites. As a main model organism, we use the cattle pathogen Theileria annulata. Infection of bovine leukocytes with this eukaryotic parasite causes cellular transformation, and infected cells share many hallmarks with cancer. Theileria-transformed cells proliferate continually, become resistant to apoptosis, and acquire a metastatic phenotype. Theileria is the only eukaryotic pathogen known to transform its host cell, and thus Theileria infection provides a unique and reversible model with which to study signalling pathways associated with transformation and cancer. By identifying host factors that are essential for Theileriadriven transformation, we expect not only to discover potential new drug targets for Tropical Theileriosis, but also to uncover novel pathways that could be involved in cancer.

In the scope of this project, we will use a newly engineered bovine genome wide single guide RNA library to perform large scale genome wide CRISPR/Cas9 knock out screens. By comparing host factors that are essential for the survival of Theileria-infected cells, but not in their non-infected counterparts, we will identify host factors and signaling pathways that are specifically required for parasite-mediated transformation. Our institute has well established expertise in the use of genome-wide screening technology (www.itpa.vetsuisse.unibe.ch/research/therapy_escape_of_cancer/index_eng.html), and in this exciting project we will apply these cutting edge techniques to bovine cells. Next, we will perform robust validation experiments including knock out and inducible shRNA depletion of candidates. The in-depth study of selected host pathways will involve a variety of advanced biochemical, cellular, proteomic and genetic approaches to better understand host cell transformation caused by the parasite.

We are looking for a highly motivated student with a strong interest in cell biology to join our group. Experience in molecular biology and biochemistry is an advantage. The position requires a degree in biology, (veterinary) medicine, biomedical sciences, biochemistry or a related field. Fluent spoken and written English are prerequisites for this position.

We offer a young and enthusiastic research group, an inspiring research environment, state-ofthe art research facilities at the attractive working location in Bern. The remuneration is in accordance with the Swiss National Science Foundation (SNF) regulations. The PhD student will be enrolled in the Graduate School of Cellular and Biomedical Sciences (http://www.gcb.unibe.ch)
at the University of Bern.

The position is available as of January 1st 2019 or by agreement.

How to apply: Please send your application, which should include a motivation letter, CV and references (letters / contact information of three references by email to: Ms. Christine Herzig, Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. ). For questions regarding the project please contact Dr. Philipp Olias ( Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. ).
Applications will be accepted until the vacancy is filled.



 


 

 

 

The Bernhard Nocht Institute (www.bnitm.de) is the largest Research Institute for Tropical Medicine in Germany and is the National Reference Centre for Tropical Pathogens, a WHO Collaborating Centre and member of the Leibniz Research Association.

The Bernhard Nocht Institute for Tropical Medicine (BNITM) in Hamburg currently has an opening for a

PhD Student (f/m/d) in the Leishmaniasis Research Group

The Leishmaniasis Research Group, headed by Dr. J. Clos, investigates the mechanisms of Leishmania life cycle control, in particular the role of chaperone proteins in the process of stressinduced stage conversion. Other topics are the mechanisms of drug resistance and the advancement of new therapeutic compounds against leishmaniasis. For further information see: https://www.bnitm.de/forschung/forschungsgruppen/molekularbiologie-undimmunologie/arbeitsgruppe-clos/

Your tasks:

The successful candidate will analyse the mechanisms of regulated protein synthesis in the context of HSP90-dependent signal transduction, using biochemical, cell biology and next generation sequencing technologies in combination with reverse and complementation genetic approaches.

Your profile:

  • We are looking for candidates holding a master's degree in biochemistry, biomedical sciences or related fields with established experimental skills in molecular cloning, protist cell biology and/or systems biology.
  • Given the international composition of the group, good English language skills, written and oral, are required.
  • Computer literacy is expected.
  • A basic knowledge of bioinformatic principles will be advantageous.

The BNITM offers a diversified training in all aspects of infection biology, but also in soft skills.The position is available immediately and the studentship is targeted for a 3-year period.
Remuneration is in accordance with German salary scheme for the public service (TV-AVHHamburg). We support our employees in achieving a work-life balance and promote the
professional equality of women and men. We strive to assist women in their scientific career, increase the number of women in research and reduce underrepresentation
in all areas and positions in general. Applicants with disabilities willbe given preference if equally qualified.


Please send your application (incl. motivation letter, CV, list of publications, references) referring to “PhD student - Leishmaniasis Research Group” until 30.11.2018 to Ms. Dvorak
( Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. ) or via postal mail to Bernhard Nocht Institute for Tropical Medicine, HR Department, Bernhard-Nocht-Straße 74, D-20359 Hamburg.
For further questions please contact Dr. J. Clos per email at Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. .

 

 


 

 

The Breloer Group "Helminth Immunology"
at the Bernhard Nocht Institute for Tropical Medicine (BNITM) in Hamburg
invites applications for the position of a

Postdoctoral researcher (m/f)

We offer a 3-years position, starting in February 2019 with the option of a 3-years extension (6 years in total). The payment and benefits are based on the TV-AVH salary scale.
Parasitic worms or helminths infect one-third of the human population. They manage to survive in immune competent hosts sometimes for decades, by actively dampening the immune response of their hosts. The Research Group "Helminth Immunology" exploits mouse models of intestinal and tissue dwelling helminth parasites to study

i) initiation and execution of innate and adaptive immune response against helminths
ii) helminth-induced countermeasures i.e. immune modulation and immune evasion
iii) the consequence of concurrent helminth infection on the immune response to third party antigens in situations of vaccination or co-infection

We are looking for an enthusiastic and highly motivated scientist who is passionate about immunology and parasitology and pursuing a scientific career to join our team. The BNITM offers a vivid and collaborative environment for research that is equipped with state-of-the-art facilities for parasitological and immunological research. The applicant will be involved in ongoing projects and also encouraged to develop independent research projects in the frame of the Helminth Immunology Group. For further information see: https://www.bnitm.de/en/research/research-groups/molecular-biology-and-immunology/breloer-group/
The applicant must hold a PhD or Dr. rer. nat. in biology, biochemistry, molecular biology or a related subject. A strong background in immunology and techniques related to infection immunology in mouse and/or human systems is advantageous. Excellent command of written and spoken English is required; German language skills are advantageous but not mandatory. Experience as postdoctoral researcher and/or experience with independent development of research projects, record of publications and/or grants will be favourable.
We support our employees in achieving a work-life balance and promote the professional equality of women and men. We strive to assist women in their scientific career, increase the number of women in research and reduce under-representation in all areas and positions in general. Applicants with disabilities will be given preference when equally qualified.
For queries regarding this position, please contact PD Dr. Minka Breloer ( Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann. )
To apply please send your application with CV, publication list, contact detail of 2-3 referees and brief outline of your research interests within the Helminth Immunology Group referring to “PostDoc Helminth-Immunology” until 01.12.2018 as a single PDF via email to Ms. Linda Dvorak: Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann.

 

 


 


PhD student position

Max Planck Institute for Developmental Biology, Tübingen

Department "Integrative Evolutionary Biology" (director Dr. Ralf J. Sommer)

Research group "Parasitic nematodes" (group leader Dr. Adrian Streit)

 

A PhD student position is available immediately in the research group of Dr. Adrian Streit (http://www.sommerlab.org/research/parasitic-nematodes.html) in the department for Integrative Evolutionary Biology (http://www.sommerlab.org/home.html) at the Max Planck Institute for Developmental Biology in Tübingen, Germany.

Topic: Comparative studies of fat storage and nutritional state dependent life history switches in parasitic nematodes of the family Strongyloididae and the free-living nematodes Prisitonchus pacificus and Caenorhabditis elegans.

The candidate should have or expect to obtain in the near future a Master's degree in Biology or a related topic. A solid knowledge of genetics and molecular biology is expected, previous experience with nematodes is not required. The working language in the department is English, knowledge of German is not required. The successful candidate will be enrolled in the institute's international PhD program and must therefore meet all requirements for admission to this program. For more information about these requirements and the program in general please see http://phd.eb.tuebingen.mpg.de.

Applications will be considered until the position is filled. All applications arriving before November 10th 2018 will be given equal consideration.

To apply, please send by Email a cover letter with a statement of interests, a brief summary of your Master thesis, a CV and the names and contact addresses of two academic references to

Dr. Adrian Streit
Max Planck Institute for Developmental Biology
Max-Planck-Ring 9
72076 Tübingen, Germany
Diese E-Mail-Adresse ist gegen Spambots geschützt! JavaScript muss aktiviert werden, damit sie angezeigt werden kann.

Short listed candidates will be invited by the PhD program office to submit full applications with all the documents.

Zuletzt aktualisiert am Mittwoch, den 14. November 2018 um 14:37 Uhr